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Volume 2
Main Index

Issue 1


Antituberculosis Agents--IV. Some Dihydrostreptomycin Derivatives
A. M. Comrie, H. C. Mital, and J. B. Stenlake
pp 1 - 14; DOI:
10.1021/jm50008a001
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The Effect of β-Diethylaminoethyl diphenylpropylacetate Hydrochloride (SKF 525-A) on the Therapeutic Action of a Variety of Antibacterial, Antiviral or Antiprotozoal Drugs
J. M. Thorp, E. Weston Hurst, and A. R. Martin
pp 15 - 30; DOI:
10.1021/jm50008a002
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Compounds Related to Pethidine--IV. New Genaral Chemical Methods of Increading the Analgesic Activity of Pethidine
Paul A J. and Nathan B. Eddy
pp 31 - 45; DOI:
10.1021/jm50008a003
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N-Pantoyl-(substituted)amines, Pantothenic Acid Analogues
John D. Fissekis, Charles G. Skinner, and William Shive
pp 47 - 56; DOI:
10.1021/jm50008a004
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The Effects of Alkyl Substitution in Drugs--I. Substituted Dimethylaminoethyl Benzhydryl Ethers
A. F. Harms and W. Th. Nauta
pp 57 - 77; DOI:
10.1021/jm50008a005
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New Derivatives of 1-Phenylpyrrole of Pharmacological Interest
Giovanna Morelli and M. Luisa Stein
pp 79 - 90; DOI:
10.1021/jm50008a006
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Enzymatic Hydrolysis of Lactoyl- and Glyceroylcholines
Andrew Lasslo, Anne L. Meyer, and B. V. Rama Sastry
pp 91 - 98; DOI:
10.1021/jm50008a007
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Antiviral Compounds--II. Reaction of 4-Biphenylglyoxal with p-Aminobenzoic Acid and Related Structures
G. Cavallini, E. Massarani, and D. Nardi
pp 99 - 106; DOI:
10.1021/jm50008a008
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Derivatives of N-Methylpiperidine
Andrew Lasslo and Pauline D. Waller
pp 107 - 110; DOI:
10.1021/jm50008a009
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Book Review
Raymond Bennett
pp 111 - 112; DOI:
10.1021/jm50008a010
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Issue 2


Derivatives of 2-Styrylquinoline
M. V. Rubtsov, G. N. Pershin, N. A. Yanbuktin, L. A. Pelenitsina, T. J. Gurevich, N. A. Novitskaya, S. N. Milovanova, and S. A. Vichkanova
pp 113 - 131; DOI:
10.1021/jm50009a001
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Monoamine Oxidase Inhibitors--I. 1-Alkyl and 1-Aralkyl-2-(picolinoyl and 5-methyl-3-isoxazolylcarbonyl)hydrazines
Thomas S. Gardner, E. Wenis, and John Lee
pp 133 - 145; DOI:
10.1021/jm50009a002
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The Effects of Alkyl substitution in Drugs--II. The Action of some Substituted β-Dimethylaminoethyl benzhydryl Ethers against the Tremor induced by 1,4-Di-N-pyrrolidino-2-butyne
M. C. De Jonge, H. M. Tersteege, A. F. Harms, A. B. H. Funcke, and W. Th. Nauta
pp 147 - 152; DOI:
10.1021/jm50009a003
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Antituberculosis Agents--V. Streptidine-β-Hexosides and Related Compounds
A. M. Comrie, H. C. Mital, and J. B. Stenlake
pp 153 - 170; DOI:
10.1021/jm50009a004
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Antituberculosis Agents--VI. Streptidine-oxyethyl β-D-glucopyranoside
A. M. Comrie, H. C. Mital, and J. B. Stenlake
pp 171 - 177; DOI:
10.1021/jm50009a005
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Central Nervous System Depressants--I. 4-Alkoxy-3,5-dipropylbenoic Acids and Derivatives
Robert Bruce Moffett, Patrick H. Seay, and William Bradley Reid
pp 179 - 200; DOI:
10.1021/jm50009a006
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Central Nervous System Depressants--II. 4-Allyloxy-3,5-dialkylbenzoic Acids and Derivatives
Robert Bruce Moffett and Patrick H. Seay
pp 201 - 212; DOI:
10.1021/jm50009a007
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Central Nervous System Depressants--III. 2- and 4-Allyloxy-3,5-Disubstituted Benzoic Acids and Derivatives
Robert Bruce Moffett and Patrick H. Seay
pp 213 - 227; DOI:
10.1021/jm50009a008
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Central Nervous System Depressants--IV. 4-Allyloxy-3,5-dialkyl-benzyl Amines
Robert Bruce Moffett and Patrick H. Seay
pp 229 - 237; DOI:
10.1021/jm50009a009
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Pharmacology of the Alkaloids of Malouetia arborea (Vell.) Miers
Robert F. Raffauf, E. Macko, and O. Ribeiro
pp 239 - 240; DOI:
10.1021/jm50009a010
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Choleic Acid Complexes of Vitamins K1 and K2
G. Cilento
pp 241 - 243; DOI:
10.1021/jm50009a011
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Issue 3


Some N-Phenethyl-4-Heteroaryl-4-Piperidinols and Related Compounds
A. H. Beckett, A. F. Casy, and P. M. Phillips
pp 245 - 261; DOI:
10.1021/jm50010a001
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Some Basic Derivatives of 3-Methylflavone-8-carboxylic Acid
Paolo Da Re, Lucia Verlicchi, and Ivo Setnikar
pp 263 - 269; DOI:
10.1021/jm50010a002
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Compounds Related to Pethidine--III. Basic Ketones derived from Norpethidine
Paul A. J. Janssen, Anton H. M. Jageneau, Paul J. A. Demoen, Corn. van De Westeringh, Julienne H. M. De Cannière, Alfons H. M. Raeymaekers, Maria S. J. Wouters, Stefan Sanczuk, and Bert K. F. Hermans
pp 271 - 280; DOI:
10.1021/jm50010a003
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The U. V. Absorption Spectra of p-Aminosalicylic Acid and some Related Compounds--IV. The Ampholytic Forms of p-Aminosalicylic Aicd and some Structurally Related Compounds and their Decarboxylation
R. F. Rekker and W. Th. Nauta
pp 281 - 297; DOI:
10.1021/jm50010a004
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Potential Anticancer Agents--XXXL. The Relationship of Analogues of 1-Methyl-3-nitro-1-nitrosoguanidine (NSC-9369)
W. A. Skinner, Helen F. Gram, Mary O. Greene, Joseph Greenberg, and B. R. Baker
pp 299 - 333; DOI:
10.1021/jm50010a005
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Spasmolytie Activity of 1-Pyridylpyrroles
N. P. Buu-Hoï, Richard Rips, and R. Cavier
pp 335 - 337; DOI:
10.1021/jm50010a006
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Book Review
A. M. Brunton
pp 339 - 342; DOI:
10.1021/jm50010a007
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Issue 4


On the Mechanism of Absorption of Drugs from the Gastrointestinal Tract
Lewis S. Schanker
pp 343 - 359; DOI:
10.1021/jm50011a001
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Cholinergic Blockade as Related to Chain Length of Monoquaternary Derivatives of Atropine and Benzoyl-tropine
Lester Soyka and Laszlo Gyermek
pp 361 - 373; DOI:
10.1021/jm50011a002
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The Synthesis of Certain 9-(3-Acylamino-3-deoxy-β-D-ribofuranosyl)-6-dimethylaminopurines, Analogues of the Antibiotic Puromycin
Arlene M. Small, Henry M. Kissman, Joseph P. Joseph, and Martin J. Weiss
pp 375 - 389; DOI:
10.1021/jm50011a003
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The Preparation of Various Esters of Certain L-Phenylalanine Derivatives and their Antifungal and Antibacterial Activity
George R. Allen, B. R. Baker, Albert C. Dornbush, Joseph P. Joseph, Henry M. Kissman, and Martin J. Weiss
pp 391 - 413; DOI:
10.1021/jm50011a004
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The Preparation of Various Amides of p-Methoxy-L-phenylalanine
Henry M. Kissman and B. R. Baker
pp 415 - 423; DOI:
10.1021/jm50011a005
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Studies on Tissue Distributionm Fluorescent Properties, and Iodination of the Plant Alkaloid, Berberine
Virginia B. Schatz, Barbara C. O'Brien, William M. Chadduck, Alvin M. Kanter, Alfred Burger, and William R. Sandusky
pp 425 - 447; DOI:
10.1021/jm50011a006
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A Study of the Nicotinic Action of 3-Phenyltropane and Related Compounds
A. M. Lands and S. Archer
pp 449 - 460; DOI:
10.1021/jm50011a007
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An Hydroxylamine Analogue of Methantheline with Mydriatic Activity
Randolph T. Major and Hans-Jürgen Hess
pp 461 - 463; DOI:
10.1021/jm50011a008
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Book Reviews
Frank Hartley
pp 465 - 467; DOI:
10.1021/jm50011a009
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Issue 5


Sequential Analysis, Screening and Serendipity
John T. Litchfield
pp 469 - 492; DOI:
10.1021/jm50012a001
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O-Phosphoric Acid Esters of 3,5-Diiodotyrosine and Thyroxine
Raymond Bennett, Alfred Burger, and Chalmers L. Gemmill
pp 493 - 498; DOI:
10.1021/jm50012a002
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Structure and Activity in a Series of 2-Halogenoalkylamines
J. D. P. Graham
pp 499 - 522; DOI:
10.1021/jm50012a003
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Derivatives of 3-Pyrrolidinols--III. The Chemistry, Pharmacology, and Toxicology of some N-Substituted-3-Pyrrolidyl α-Substitutes Phenylacetates
Bernard V. Franko and Carl D. Lunsford
pp 523 - 540; DOI:
10.1021/jm50012a004
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Determination of Fluoride Ion in Femurs of Rats Receiving Organic Fluoride
Emi K. Horikawa, Richard Steelman, Thomas L. Flanagan, and Edward J. Van Loon
pp 541 - 551; DOI:
10.1021/jm50012a005
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The Synthesis of (±), (+) and (-) α-(3- Thiamorpholinyl)-benzhydrol, a New Selective Stimulant of the Central Nervous System
B. Belleau
pp 553 - 562; DOI:
10.1021/jm50012a006
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Metabolic Degradation of the Nitrofurans
H. E. Paul, V. R. Ells, F. Kopko, and R. C. Bender
pp 563 - 584; DOI:
10.1021/jm50012a007
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Pharmaeology of the Alkaloids of Excavatia coccinea (Tejsmann and Binnendijk) Mgf.
E. Macko and R. F. Raffauf
pp 585 - 587; DOI:
10.1021/jm50012a008
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Book Review
Stanley Wawzonek
pp 589 - 589; DOI:
10.1021/jm50012a009
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Issue 6


Monoamine Oxidase Inhibitors and Procedures for their Evaluation In Vivo and In Vitro
Masayori Ozaki, Herbert Weissbach, Atsuko Ozaki, Bernhard Witkop, and Sidney Udenfriend
pp 591 - 607; DOI:
10.1021/jm50013a001
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Ultraviolet Differential Spectrophotometry of Thiobarbiturates
Louis A. Williams, Allen T. Hardy, Jerry S. Cohen, and Bennie Zak
pp 609 - 615; DOI:
10.1021/jm50013a002
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The Synthesis of Substituted Arylalkylaminopropionamide Analogues of Lysergic Acid Diethylamide and their Effect upon Isolated Cholinesterase Systems
Andrew Lasslo, Pauline D. Waller, Anne L. Meyer, and B. V. Rama Sastry
pp 617 - 631; DOI:
10.1021/jm50013a003
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Potential Anticancer Agents --L. Non-Classical Antimetabolites--II. Some Factors in the Design of Exo-Alkylating Enzyme Inhibitors, partcularly of Lactic Dehydrogenase
B. R. Baker, William W. Lee, W. A. Skinner, Abelardo P. Martinez, and Ethel Tong
pp 633 - 657; DOI:
10.1021/jm50013a004
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Chemical Constitution and Anthelmintie Activity--IV. Substituted Phenothiazines
J. Cymerman Craig, M. E. Tate, G. P. Warwick, and W. P. Rogers
pp 659 - 668; DOI:
10.1021/jm50013a005
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Chemical Constitution and Anthelmintie Activity--V. Alkoxy- and Chlorophenothiazines
J. Cymerman Craig, M. E. Tate, F. W. Donovan, and W. P. Rogers
pp 669 - 680; DOI:
10.1021/jm50013a006
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Chemical Constitution and Anthelmintie Activity--VI. Some Diphenylamines and Mono- and Dicyclic Analogues of Phenothiazine
J. Cymerman Craig, M. E. Tate, G. P. Warwick, and W. P. Rogers
pp 681 - 685; DOI:
10.1021/jm50013a007
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3-Phenylcyclobutylamine
Alfred Burger and Raymond Bennett
pp 687 - 691; DOI:
10.1021/jm50013a008
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